Codeine and promethazine is a mixture drugs made use of to take care of cold or allergy signs or symptoms including runny nose, sneezing, and cough.

Significant Uncomfortable side effects may very well be extra probable in older adults and people who are overweight, malnourished, or debilitated.

Promethazine Promethazine competitively antagonize H1 receptors located in most of the smooth muscle such as the gastrointestinal tract, uterus, massive blood vessels and bronchial muscle.

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Codeine produces peripheral vasodilation which may end in orthostatic hypotension or syncope. Manifestations of histamine release and/or peripheral vasodilation may possibly include things like pruritus, flushing, purple eyes and sweating and/or orthostatic hypotension.

Utilize other supportive steps (such as oxygen and vasopressors) while in the administration of circulatory shock and pulmonary edema as indicated. Cardiac arrest or arrhythmias will require advanced existence-aid strategies. Gastric emptying may very well be useful in taking away unabsorbed drug.

Endocrine/Metabolic: Conditions of serotonin syndrome, a most likely existence-threatening condition, are noted all through concomitant utilization of opioids with serotonergic prescription drugs.

Indicators and signs or symptoms of overdosage with promethazine range from delicate depression in the central nervous process and cardiovascular process to profound hypotension, respiratory despair, unconsciousness and unexpected Demise.

Codeine has great antitussive activity, Despite the fact that fewer than that of morphine at equal doses. It is actually used in preference to morphine, for the reason that Unwanted effects are infrequent at the usual antitussive dose of codeine.

Promethazine VC with Codeine can gradual or halt read more your respiratory, and Demise may possibly arise. Someone caring for you must seek out emergency healthcare interest When you have slow respiratory with prolonged pauses, blue colored lips, or If you're hard to awaken.

Just before getting this medication, notify your doctor or pharmacist If you're allergic to any of its components; or to opioid soreness relievers (for instance morphine); or Should you have another allergy symptoms.

Therapy of Overdose Treatment of overdosage is pushed by the overall medical presentation, and consists of discontinuation of Promethazine with Codeine Oral Option collectively with establishment of ideal therapy. Give Principal attention to your reestablishment of sufficient respiratory Trade through provision of a patent and guarded airway plus the institution of assisted or controlled air flow.

Evaluate Each and every patient's chance before prescribing Promethazine with Codeine Oral Solution, prescribe Promethazine with Codeine Oral Option to the shortest duration that is definitely steady with individual client remedy goals, watch all individuals consistently for the development of addition or abuse, and refill only after reevaluation of the need for ongoing therapy. [see Warnings and Safety measures (5.1)]

Notify your medical doctor If the cough isn't going to get well in 5 times. Also, notify your physician if your ailment will get worse, or When you've got a headache that doesn't disappear, fever, or rash. These may very well be signs or symptoms of a significant professional medical problem and should be checked by a doctor.